Analysis of Pharmaceuticals by Capillary Electrophoresis by Kevin D. Altria (auth.)

By Kevin D. Altria (auth.)

During the 1980's the research of prescription drugs was once ruled by way of excessive Perfor­ mance Liquid Chromatography (HPLC). different separative options resembling gasoline Chromato­ graphy and skinny Layer Chromatography provided possible choices yet their quantitative capabili­ ties and/or solute variety couldn't procedure that of HPLC. nearly all of prescription drugs are ionic and it might be moderate to imagine that electrophoresis could be invaluable within the research of prescription drugs. despite the fact that, the electrophore­ tic tools on hand within the 1980's have been labour extensive and hired post-separation detection strategies. throughout the overdue 1980's and early 1990's vast examine used to be con­ ducted into the chances of engaging in electrophoretic separations in capillaries. This technique allowed online detection and will be played on totally automatic apparatus. This learn resulted in the arrival of contemporary day capillary electrophoresis (CE) tools which supply related functionality and automation degrees to that of HPLC. learn was once additionally concerned about constructing purposes for CE and specific realization used to be paid to functions in the pharmaceutical research quarter. those functions proved that CE can be utilized to a variety of drug kinds together with water insoluble and impartial compounds. the power to accomplish effective chiral separations of gear additionally elevated the recognition of the process. CE with oblique UV detection has turn into demonstrated as an easy and powerful substitute to ion-exchange chromatography for the decision of small inorganic or natural ions.

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Good precision was obtained using either aminobenzoic acid or imidazole as the internal standard. 1 shows a typical separation obtained under these conditions. 2). Levels of isoxsuprine in tablets were determined by analysing aqueous extracts containing an internal standard (6). 3 % result. Similar good performance has been reported in the determination of cimetidine (16). Levels of domperidone were assayed (3) in various formulations using a citrate-phosphate electrolyte (pH 4) and the assay results were in good agreement with label claim and HPLC data.

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