By Rosaleen Anderson, Paul Groundwater, Adam Todd, Alan Worsley
Antibacterial brokers act opposed to bacterial an infection both through killing the bacterium or by way of arresting its progress. They do that by means of focusing on bacterial DNA and its linked strategies, attacking bacterial metabolic strategies together with protein synthesis, or interfering with bacterial cellphone wall synthesis and function.
Antibacterial Agents is a necessary advisor to this crucial category of chemotherapeutic medicinal drugs. Compounds are organised in accordance with their aim, which is helping the reader comprehend the mechanism of motion of those medicines and the way resistance can come up. The ebook makes use of an built-in “lab-to-clinic” technique which covers drug discovery, resource or synthesis, mode of motion, mechanisms of resistance, scientific facets (including hyperlinks to present instructions, major drug interactions, cautions and contraindications), prodrugs and destiny improvements.
Agents coated include:
- agents focusing on DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents
- agents focusing on metabolic approaches - sulfonamide antibacterial brokers and trimethoprim
- agents focusing on protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones
- agents focusing on telephone wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin
Antibacterial Agents will discover a position at the bookshelves of scholars of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.
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Extra info for Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications
Resistance to quinolones arises due to alterations in the DNA gyrase (via mutations in the quinolone resistance-determining region (QRDR) of the gyrA gene), and similar mutations which decrease quinolone binding have been described in topoisomerase IV (in the parC gene). The quinolones are generally well tolerated, but some of the newer generations have been associated with serious adverse effects, such as hepatotoxicity and QT interval prolongation (cardiotoxicity). Some quinolones should not be routinely used in combination with theophylline because of the risk of developing theophylline toxicity.
2000), but bacteria have also developed resistance to the quinolones through decreased cellular uptake due to the impermeability of the cell membrane.
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